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htt plasmids p426 25q gpd  (Addgene inc)


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    Addgene inc htt plasmids p426 25q gpd
    Htt Plasmids P426 25q Gpd, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/p426+25q+gpd/pm37732342-56-25-42?v=Addgene+inc
    Average 93 stars, based on 7 article reviews
    htt plasmids p426 25q gpd - by Bioz Stars, 2026-07
    93/100 stars

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    Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models <t>46Q,</t> 72Q and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.
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    Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, <t>72Q</t> and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.
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    25q gpd  (Addgene inc)
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    Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, <t>72Q</t> and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.
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    Image Search Results


    Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, 72Q and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.

    Journal: Disease Models & Mechanisms

    Article Title: Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

    doi: 10.1242/dmm.049492

    Figure Lengend Snippet: Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, 72Q and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.

    Article Snippet: A total of 8×10 8 cells was taken for transformation with p426 25Q GPD, p426 46Q GPD, p426 72Q GPD and p426 103Q GPD (Addgene plasmids #1181 , #1182 , #1183 and #1184 , respectively).

    Techniques:

    Metabolite set enrichment analysis (MESA) and shared deregulated pathways. (A) Yeast metabolomics (present study) show significantly different levels of metabolites in yeasts 46Q, 72Q and 103Q compared to 25Q. (B) MSEA showing shared pathways deregulated in 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q. (C) Metabolomics pathway overlaps determined in our study (yeasts 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q) and literature show pathways commonly deregulated in yeast 103Q compared to yeast 25Q. (D,E) Comparative analysis of significantly enriched metabolic pathways identified in a HD mouse model (D) and in HD patients (E). (F) Metabolomics of previously published deregulated metabolic pathways in human (literature) and deregulated pathways identified in our HD patient cohort (present study), showing an overlap of three deregulated pathways. (G) Plotted is the overlap of deregulated metabolic pathways identified in yeast and mouse HD models, and HD patients. BS, brain stem; CB, cerebellum; CSF, cerebrospinal fluid; CT, cortex; FL, frontal lobe; ST, striatum.

    Journal: Disease Models & Mechanisms

    Article Title: Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

    doi: 10.1242/dmm.049492

    Figure Lengend Snippet: Metabolite set enrichment analysis (MESA) and shared deregulated pathways. (A) Yeast metabolomics (present study) show significantly different levels of metabolites in yeasts 46Q, 72Q and 103Q compared to 25Q. (B) MSEA showing shared pathways deregulated in 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q. (C) Metabolomics pathway overlaps determined in our study (yeasts 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q) and literature show pathways commonly deregulated in yeast 103Q compared to yeast 25Q. (D,E) Comparative analysis of significantly enriched metabolic pathways identified in a HD mouse model (D) and in HD patients (E). (F) Metabolomics of previously published deregulated metabolic pathways in human (literature) and deregulated pathways identified in our HD patient cohort (present study), showing an overlap of three deregulated pathways. (G) Plotted is the overlap of deregulated metabolic pathways identified in yeast and mouse HD models, and HD patients. BS, brain stem; CB, cerebellum; CSF, cerebrospinal fluid; CT, cortex; FL, frontal lobe; ST, striatum.

    Article Snippet: A total of 8×10 8 cells was taken for transformation with p426 25Q GPD, p426 46Q GPD, p426 72Q GPD and p426 103Q GPD (Addgene plasmids #1181 , #1182 , #1183 and #1184 , respectively).

    Techniques:

    Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, 72Q and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.

    Journal: Disease Models & Mechanisms

    Article Title: Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

    doi: 10.1242/dmm.049492

    Figure Lengend Snippet: Metabolomic study using an HD yeast model. (A-F) Heat maps of targeted metabolomics in Htt yeast models 46Q, 72Q and 103Q compared to that of 25Q in positive and negative modes. Altered metabolites in 46Q compared to 25Q in positive (A) and negative (B) mode. Altered metabolites in 72Q compared to 25Q in positive (C) and negative mode (D). (E) Altered metabolites in 103Q compared to 25Q in positive (E) and negative (F) mode.

    Article Snippet: A total of 8×10 8 cells was taken for transformation with p426 25Q GPD, p426 46Q GPD, p426 72Q GPD and p426 103Q GPD (Addgene plasmids #1181 , #1182 , #1183 and #1184 , respectively).

    Techniques:

    Metabolite set enrichment analysis (MESA) and shared deregulated pathways. (A) Yeast metabolomics (present study) show significantly different levels of metabolites in yeasts 46Q, 72Q and 103Q compared to 25Q. (B) MSEA showing shared pathways deregulated in 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q. (C) Metabolomics pathway overlaps determined in our study (yeasts 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q) and literature show pathways commonly deregulated in yeast 103Q compared to yeast 25Q. (D,E) Comparative analysis of significantly enriched metabolic pathways identified in a HD mouse model (D) and in HD patients (E). (F) Metabolomics of previously published deregulated metabolic pathways in human (literature) and deregulated pathways identified in our HD patient cohort (present study), showing an overlap of three deregulated pathways. (G) Plotted is the overlap of deregulated metabolic pathways identified in yeast and mouse HD models, and HD patients. BS, brain stem; CB, cerebellum; CSF, cerebrospinal fluid; CT, cortex; FL, frontal lobe; ST, striatum.

    Journal: Disease Models & Mechanisms

    Article Title: Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

    doi: 10.1242/dmm.049492

    Figure Lengend Snippet: Metabolite set enrichment analysis (MESA) and shared deregulated pathways. (A) Yeast metabolomics (present study) show significantly different levels of metabolites in yeasts 46Q, 72Q and 103Q compared to 25Q. (B) MSEA showing shared pathways deregulated in 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q. (C) Metabolomics pathway overlaps determined in our study (yeasts 25Q vs 46Q, 25Q vs 72Q and 25Q vs 103Q) and literature show pathways commonly deregulated in yeast 103Q compared to yeast 25Q. (D,E) Comparative analysis of significantly enriched metabolic pathways identified in a HD mouse model (D) and in HD patients (E). (F) Metabolomics of previously published deregulated metabolic pathways in human (literature) and deregulated pathways identified in our HD patient cohort (present study), showing an overlap of three deregulated pathways. (G) Plotted is the overlap of deregulated metabolic pathways identified in yeast and mouse HD models, and HD patients. BS, brain stem; CB, cerebellum; CSF, cerebrospinal fluid; CT, cortex; FL, frontal lobe; ST, striatum.

    Article Snippet: A total of 8×10 8 cells was taken for transformation with p426 25Q GPD, p426 46Q GPD, p426 72Q GPD and p426 103Q GPD (Addgene plasmids #1181 , #1182 , #1183 and #1184 , respectively).

    Techniques: